研究業績

HNF4α is required for Tkfc promoter activation by ChREBP.
Tsukamoto R, Watanabe K, Kodaka M, Iwase M, Sakiyama H, Inoue Y, Suzuki T, Yamamoto Y, Shimizu M, Sato R, Inoue J.
Biosci Biotechnol Biochem. 2024 Jul 22;88(8):941-947.

Establishment of a cell culture platform for human liver organoids and its application for lipid metabolism research.
Kuboyama-Sasaki A, Takahashi Y, Xia C, Hiro K, Kobayashi T, Ohdan H, Shimizu M, Yamauchi Y, Kiyono H, Sato R.
Biotechnol J. 2024 Jan;19(1):e2300365.

Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies. Takahashi Y, Inoue Y, Sato S, Okabe T, Kojima H, Kiyono H, Shimizu M, Yamauchi Y, Sato R.
Sci Rep. 2023 Apr 3;13(1):5407.

Skeletal muscle releases extracellular vesicles with distinct protein and microRNA signatures that function in the muscle microenvironment. Watanabe S, Sudo Y, Makino T, Kimura S, Tomita K, Noguchi M, Sakurai H, Shimizu M, Takahashi Y, Sato R, Yamauchi Y.
PNAS Nexus. 2022 Aug 26;1(4):pgac173.

Hydroxylation site-specific and production-dependent effects of endogenous oxysterols on cholesterol homeostasis: Implications for SREBP-2 and LXR.
Saito H, Tachiura W, Nishimura M, Shimizu M, Sato R, Yamauchi Y.
J Biol Chem. 2023 Jan;299(1):102733.

Lactic acid bacteria-derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids.
Noguchi M, Shimizu M, Lu P, Takahashi Y, Yamauchi Y, Sato S, Kiyono H, Kishino S, Ogawa J, Nagata K, Sato R.
J Biol Chem. 2022 Nov;298(11):102534.

Pathophysiological levels of GDF11 activate Smad2/Smad3 signaling and induce muscle atrophy in human iPSC-derived myocytes.
Honda M, Makino T, Zhao X, Matsuto M, Sakurai H, Takahashi Y, Shimizu M, Sato R, Yamauchi Y.
Am J Physiol Cell Physiol. 2022 Nov 1;323(5):C1402-C1409.

Nobiletin enhances plasma Interleukin-6 and C-X-C motif chemokine ligand 1 levels that are increased by treadmill running.
Suzuki T, Shimizu M, Yamauchi Y, Sato R.
Food Sci Nutr. 2022 Mar 24;10(7):2360-2369.

Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies.
Takahashi Y, Noguchi M, Inoue Y, Sato S, Shimizu M, Kojima H, Okabe T, Kiyono H, Yamauchi Y, Sato R.
iScience. 2022 Jun 7;25(7):104542.

Sesamin and Hepatic Metabolites Derived from Sesamin and Episesamin Antagonize Farnesoid X Receptor and Reduce the Expression of Gluconeogenesis-Related Genes.
Sasaki T, Okuda M, Hong TW, Watanabe Y, Takahashi Y, Shimizu M, Yamauchi Y, Sato R.
J Nutr Sci Vitaminol (Tokyo). 2022;68(1):55-64.

Endocrine Fibroblast Growth Factors in Relation to Stress Signaling.
Shimizu M, Sato R.
Cells. 2022 Feb 1;11(3):505.

Maslinic acid activates mTORC1 and human TGR5 and induces skeletal muscle hypertrophy.
Murata S, Sasaki T, Yamauchi Y, Shimizu M, Sato R.
Biosci Biotechnol Biochem. 2021 Oct 21;85(11):2311-2321.

Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.
Watanabe Y, Sasaki T, Miyoshi S, Shimizu M, Yamauchi Y, Sato R.
J Biol Chem. 2021 Aug;297(2):100989.

Comparison of gene expression and activation of transcription factors in organoid-derived monolayer intestinal epithelial cells and organoids.
Takahashi Y, Inoue Y, Kuze K, Sato S, Shimizu M, Kiyono H, Yamauchi Y, Sato R.
Biosci Biotechnol Biochem. 2021 Sep 22;85(10):2137-2144.

Orange peel extract reduces the inflammatory state of skeletal muscle after downhill running via an increase in IL-1RA. Suzuki T, Shimizu M, Yamauchi Y, Sato R.
Biosci Biotechnol Biochem. 2021 May 25;85(6):1506-1513.

Polymethoxyflavones in orange peel extract prevent skeletal muscle damage induced by eccentric exercise in rats. Suzuki T, Shimizu M, Yamauchi Y, Sato R.
Biosci Biotechnol Biochem. 2021 Feb 18;85(2):440-446.

Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice. Sasaki T, Watanabe Y, Kuboyama A, Oikawa A, Shimizu M, Yamauchi Y, Sato R.
J Biol Chem. 2021 Jan-Jun;296:100131.

Functional effect of nobiletin as a food-derived allosteric modulator of mouse CRFR2β in skeletal muscle. Chikazawa M, Moriwaki Y, Uramoto M, Yamauchi Y, Shimizu M, Shimizu K, Sato R.
Biochem Biophys Res Commun. 2020 Aug 20;529(2):328-334.

Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP. Kuan YC, Takahashi Y, Maruyama T, Shimizu M, Yamauchi Y, Sato R.
J Biol Chem. 2020 Mar 20;295(12):3918-3928.

Bridging molecules are secreted from the skeletal muscle and potentially regulate muscle differentiation. Chikazawa M, Shimizu M, Yamauchi Y, Sato R.
Biochem Biophys Res Commun. 2020 Jan 29;522(1):113-120.

Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins. Iwase M, Watanabe K, Shimizu M, Suzuki T, Yamamoto Y, Inoue J, Sato R.
Biosci Biotechnol Biochem. 2019 Sep;83(9):1740-1746.

FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions.
Maruyama R, Shimizu M, Hashidume T, Inoue J, Itoh N, Sato R.
J Nutr Sci Vitaminol (Tokyo). 2018;64(3):200-208.

Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins. Inoue J, Miyata S, Shimizu M, Sato R.
Biosci Biotechnol Biochem. 2018 Sep;82(9):1591-1598.

The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice. Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, Mori K, Sato R.
J Biol Chem. 2018 Jun 29;293(26):10322-10332.

The expression of Transmembrane Protein 100 is regulated by alterations in calcium signaling rather than endoplasmic reticulum stress. Kuboyama A, Sasaki T, Shimizu M, Inoue J, Sato R.
Biosci Biotechnol Biochem. 2018 Aug;82(8):1377-1383.

Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model. Sasaki T, Mita M, Ikari N, Kuboyama A, Hashimoto S, Kaneko T, Ishiguro M, Shimizu M, Inoue J, Sato R.
PLoS One. 2017 Jun 8;12(6):e0179226.

BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice. Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Hirano S, Shimizu M, Kominami R, Sato R.
Biosci Biotechnol Biochem. 2017 May;81(5):922-930.

Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein. Kuan YC, Hashidume T, Shibata T, Uchida K, Shimizu M, Inoue J, Sato R.
J Biol Chem. 2017 Feb 17;292(7):3016-3028.

清水 誠　抗肥満ホルモンFGF21の転写制御と機能性食品成分　非栄養素の分子栄養学（建帛社）123-133. 2017.

Identification of BCL11B as a regulator of adipogenesis. Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Nakai Y, Hirano S, Shimizu M, Kominami R, Sato R.
Sci Rep. 2016 Sep 2;6:32750.

Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects. Hashidume T, Kato A, Tanaka T, Miyoshi S, Itoh N, Nakata R, Inoue H, Oikawa A, Nakai Y, Shimizu M, Inoue J, Sato R.
Sci Rep. 2016 Jun 17;6:28183.

Kaempferol stimulates gene expression of low-density lipoprotein receptor through activation of Sp1 in cultured hepatocytes.
Ochiai A, Miyata S, Iwase M, Shimizu M, Inoue J, Sato R.
Sci Rep. 2016 Apr 25;6:24940.

Fibroblast growth factor 21 induction by activating transcription factor 4 is regulated through three amino acid response elements in its promoter region. Maruyama R, Shimizu M, Li J, Inoue J, Sato R.
Biosci Biotechnol Biochem. 2016 May;80(5):929-34.

Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis. Maruyama R, Shimizu M, Ishijima T, Nakai Y, Inoue J, Sato R.
Biosci Biotechnol Biochem. 2016 Jun;80(6):1149-54.

Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation. Takahashi Y, Shinoda A, Kamada H, Shimizu M, Inoue J, Sato R.
Sci Rep. 2016 Feb 15;6:20975.

Allyl isothiocyanate suppresses the proteolytic activation of sterol regulatory element-binding proteins and de novo fatty acid and cholesterol synthesis. Miyata S, Inoue J, Shimizu M, Sato R.
Biosci Biotechnol Biochem. 2016 May;80(5):1006-11.

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL.
Mol Endocrinol. 2015 Feb;29(2):213-23.

Piperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding Proteins. Ochiai A, Miyata S, Shimizu M, Inoue J, Sato R.
PLoS One. 2015 Oct 2;10(10):e0139799.

Identification of the Flavonoid Luteolin as a Repressor of the Transcription Factor Hepatocyte Nuclear Factor 4α. Li J, Inoue J, Choi JM, Nakamura S, Yan Z, Fushinobu S, Kamada H, Kato H, Hashidume T, Shimizu M, Sato R.
J Biol Chem. 2015 Sep 25;290(39):24021-35.

Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation. Miyata S, Inoue J, Shimizu M, Sato R.
J Biol Chem. 2015 Aug 14;290(33):20565-79.

Selective Regulation of FGF19 and FGF21 Expression by Cellular and Nutritional Stress. Shimizu M, Morimoto H, Maruyama R, Inoue J, Sato R.
J Nutr Sci Vitaminol (Tokyo). 2015;61(2):154-60.

Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ. Shimizu M, Li J, Inoue J, Sato R.
PLoS One. 2015 Apr 15;10(4):e0121784.

Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle. Sasaki T, Nakata R, Inoue H, Shimizu M, Inoue J, Sato R.
Am J Physiol Endocrinol Metab. 2014 May 1;306(9):E1085-92.

清水 誠、井上 順、佐藤 隆一郎　グルタミンによる細胞維持・増殖調節機構　≪最新≫動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術（技術情報協会）2014.

ATF6α stimulates cholesterogenic gene expression and de novo cholesterol synthesis. Maruyama R, Kamoshida Y, Shimizu M, Inoue J, Sato R.
Biosci Biotechnol Biochem. 2013;77(8):1734-8.

FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. Shimizu M, Li J, Maruyama R, Inoue J, Sato R.
Biochem J. 2013 Feb 15;450(1):221-9.

5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element. Yashiro T, Nanmoku M, Shimizu M, Inoue J, Sato R.
Atherosclerosis. 2013 Jan;226(1):95-101.

4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis. Miyata S, Inoue J, Shimizu M, Sato R.
FEBS Lett. 2012 Jun 21;586(13):1778-82.

Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins. Yashiro T, Nanmoku M, Shimizu M, Inoue J, Sato R.
Atherosclerosis. 2012 Feb;220(2):369-74.

Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes. Inoue J, Ito Y, Shimada S, Satoh SI, Sasaki T, Hashidume T, Kamoshida Y, Shimizu M, Sato R. FEBS J. 2011 Aug;278(15):2739-50.

Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet. Ono E, Inoue J, Hashidume T, Shimizu M, Sato R.
Biochem Biophys Res Commun. 2011 Jul 8;410(3):677-81.

Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation. Inoue J, Yamasaki K, Ikeuchi E, Satoh S, Fujiwara Y, Nishimaki-Mogami T, Shimizu M, Sato R.
Mol Endocrinol. 2011 Jun;25(6):995-1005.

Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3'-untranslated region and AU-rich element-binding protein. Yashiro T, Yokoi Y, Shimizu M, Inoue J, Sato R.
Biochem Biophys Res Commun. 2011 Jun 3;409(2):155-9.

清水 誠、佐藤 隆一郎　オーファン受容体の内在性リガンド（核内受容体PPARの内在性リガンドの同定）（総説）栄養学レビュー 68. 316-318. 2011.

Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair. Shimizu M, Akter MH, Emi Y, Sato R, Yamaguchi T, Hirose F, Osumi T.
J Biochem. 2006 Mar;139(3):563-73.

Aspects of the regulatory mechanisms of PPAR functions: analysis of a bidirectional response element and regulation by sumoylation. Shimizu M, Yamashita D, Yamaguchi T, Hirose F, Osumi T.
Mol Cell Biochem. 2006 Jun;286(1-2):33-42.

[Mechanism for the action of PPARs]. Yamashita D, Shimizu M, Osumi T.
Nihon Rinsho. 2005 Apr;63(4):536-7.

The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain. Yamashita D, Yamaguchi T, Shimizu M, Nakata N, Hirose F, Osumi T.
Genes Cells. 2004 Nov;9(11):1017-29.

SKIP modifies gene expression by affecting both transcription and splicing. Nagai K, Yamaguchi T, Takami T, Kawasumi A, Aizawa M, Masuda N, Shimizu M, Tominaga S, Ito T, Tsukamoto T, Osumi T.
Biochem Biophys Res Commun. 2004 Apr 2;316(2):512-7.

Tissue-selective, bidirectional regulation of PEX11 alpha and perilipin genes through a common peroxisome proliferator response element. Shimizu M, Takeshita A, Tsukamoto T, Gonzalez FJ, Osumi T.
Mol Cell Biol. 2004 Feb;24(3):1313-23.